Projects per year
Abstract / Description of output
Peptide nucleic acids have become, arguably, one of the most interesting of DNA mimics. Herein the efficient solution phase synthesis of four novel 1-(4,4-dimethyl-2,6-dioxacyclohexylidene)ethyl/4-methoxytrityl (Dde/Mmt) protected PNA monomers is reported which were then used to synthesise PNA-peptide conjugates through a mild Dde deprotection strategy, which was fully orthogonal to Fmoc chemistry, allowing at will Fmoc peptide and Dde-PNA synthesis. (c) 2005 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 8295-8305 |
Number of pages | 11 |
Journal | Tetrahedron |
Volume | 61 |
Issue number | 34 |
DOIs | |
Publication status | Published - 22 Aug 2005 |
Keywords / Materials (for Non-textual outputs)
- PNA
- Dde
- Fmoc
- orthogonality
- conjugate
- peptide
- SOLID-PHASE SYNTHESIS
- NUCLEIC-ACID
- POLYAMIDE
- THYMINE
- DNA
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Dive into the research topics of 'Dde-protected PNA monomers, orthogonal to Fmoc, for the synthesis of PNA-peptide conjugates'. Together they form a unique fingerprint.Projects
- 1 Finished
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Interfacing DNA arrays and combinatorial libraries for high-content enzymatic screening
Bradley, M.
1/03/05 → 31/05/05
Project: Research