Deaths due to absence of an affordable antitoxin for plant poisoning

Michael Eddleston, Lalith Senarathna, Fahim Mohamed, Nick Buckley, Edmund Juszczak, M H Rezvi Sheriff, Ariaranee Ariaratnam, Senaka Rajapakse, David Warrell, K Rajakanthan

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

There is a severe shortage of affordable antivenoms and antitoxins in the developing world. An anti-digoxin antitoxin for oleander poisoning was introduced in Sri Lanka in July, 2001, but because of its cost, stocks ran out in July, 2002. We looked at the effect of its introduction and withdrawal on case fatality, and determined its cost-effectiveness. The antitoxin strikingly reduced the case fatality; its absence resulted in a three-fold rise in deaths. At the present price of US2650 dollars per course, every life saved cost 10209 dollars and every life year cost 248 dollars. Reduction of the antitoxin's price to 400 dollars would reduce costs to 1137 dollars per life gained; a further reduction to 103 dollars would save money for every life gained. Treatments for poisoning and envenoming should be included in the present campaign to increase availability of affordable treatments in the developing world.

Original languageEnglish
Pages (from-to)1041-4
Number of pages4
JournalThe Lancet
Issue number9389
Publication statusPublished - 27 Sept 2003

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Antitoxins
  • Arrhythmias, Cardiac
  • Cardiac Pacing, Artificial
  • Cause of Death
  • Coronary Care Units
  • Cost-Benefit Analysis
  • Costs and Cost Analysis
  • Developing Countries
  • Drug Costs
  • Female
  • Health Care Costs
  • Humans
  • Male
  • Middle Aged
  • Nerium
  • Plant Poisoning
  • Prospective Studies
  • Sri Lanka
  • Thevetia
  • Treatment Outcome


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