Decidual Neutrophil Infiltration Is Not Required for Preterm Birth in a Mouse Model of Infection-Induced Preterm Labor

Sara Rinaldi, Rob D Catalano, Jean Wade, Adriano G Rossi, Jane E Norman

Research output: Contribution to journalArticlepeer-review

Abstract

Parturition is associated with a leukocyte influx into the intrauterine tissues; however, the exact role these leukocytes play in the onset of labor remains unclear. Neutrophil infiltration of the uteroplacental tissues has been particularly associated with infection-associated preterm labor (PTL) in both women and mouse models. In this study, we investigated the role of neutrophils in a mouse model of infection-induced PTL. Intrauterine administration of LPS on day 17 of gestation resulted in a 7-fold increase in the number of decidual neutrophils compared with control mice receiving PBS (p
Original languageEnglish
Pages (from-to)2315-2325
JournalJournal of Immunology
Volume192
Issue number5
DOIs
Publication statusPublished - 1 Mar 2014

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