Decoding Movement States in Stepping Cycles Based on Subthalamic LFPs in Parkinsonian Patients

Huiling Tan, Petra Fischer, Syed A Shah, Diego Vidaurre, Mark W Woolrich, Peter Brown

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gait disturbances are a prominent feature of Parkinson's disease (PD), often refractory to medication or continuous deep brain stimulation (DBS) on basal ganglia targets such as the subthalamic nucleus (STN). Here we sought to identify movement states during stepping cycles, such as left leg stance and right leg stance. To this end we analyzed local field potential (LFP) activity in STN using a combination of the multivariate autoregressive (MAR) model and the Hidden Markov model (HMM). Our results confirm that information is present in the STN related to movement states in stepping cycles, and that it is feasible to decode movement states based on STN LFPs recorded from DBS electrodes. This information can be used to implement temporally flexible stimulation strategies in order to facilitate patterns of neural modulation associated with better gait performance.

Original languageEnglish
Title of host publication2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Pages1384-1387
Number of pages4
Volume2018
DOIs
Publication statusPublished - 29 Oct 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Honolulu, United States
Duration: 18 Jul 201821 Jul 2018
https://embc.embs.org/2018/

Publication series

NameConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISSN (Print)1557-170X

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC 2018
CountryUnited States
CityHonolulu
Period18/07/1821/07/18
Internet address

Fingerprint

Dive into the research topics of 'Decoding Movement States in Stepping Cycles Based on Subthalamic LFPs in Parkinsonian Patients'. Together they form a unique fingerprint.

Cite this