Decompensated liver cirrhosis

Research output: Contribution to journalLiterature reviewpeer-review


The incidence of liver disease continues to increase and is now one of the leading causes of death in the United Kingdom. The increasing prevalence of viral hepatitis combined with a surge in the incidence of both alcohol and obesity related liver disease mean that critical care units are increasingly being called upon to assist in managing those with life-threatening complications of end-stage liver disease. Decompensated cirrhosis is not a single organ illness but a complex multisystem disorder typified by impaired immunity, malnutrition and multiorgan failure and presents a significant challenge to the critical care physician. In this article we describe the epidemiology, aetiology, and pathophysiology of decompensated liver disease and describe the management strategies of a range of resulting clinical complications.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalAnaesthesia and Intensive Care Medicine
Issue number4
Publication statusPublished - 1 Apr 2015


  • Decompensated liver disease
  • encephalopathy
  • liver cirrhosis
  • liver transplant


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