Decrease in the alpha(1)-proteinase inhibitor spi3 in equine bronchoalveolar lavage fluid

Elspeth Milne, Alan Pemberton, Padraic Dixon, Bruce McGorum, C L Scudmore, H R P Miller

Research output: Contribution to journalArticlepeer-review

Abstract

The alpha(1)-proteinase inhibitors of trypsin, Spi1, Spi3A, and Spi3B, in bronchoalveolar lavage fluid (BALF) and serum of horses were separated by electrophoresis, and their proportions were quantified in 12 control horses and 12 with chronic obstructive pulmonary disease (COPD). A significantly lower proportion of Spi3B (P < 0.05) and higher proportion of Spi1 (P < 0.02 to P < 0.01) were detected in BALF, compared with serum, in control and COPD-affected horses and appeared to be attributable to reduced Spi3 activity in BALF. There was no significant difference between the control and COPD groups in this respect, indicating that the decrease in Spi3 may be a physiologic phenomenon. The differences observed may be associated with proteolytic damage to or preferential complex formation by Spi3.

Original languageEnglish
Pages (from-to)1377-1380
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume55
Issue number10
Publication statusPublished - Oct 1994

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