Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats

J L W Yau, T Olsson, Richard Morris, J Noble, J R Seckl

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Hippocampal NGFI-A gene expression is increased following the induction of long-term potentiation, a form of activity-dependent synaptic plasticity that has been implicated in learning. In this study, we show a positive correlation between spatial learning and the constitutive expression of NGFI-A mRNA, selectively in CA1 pyramidal neurons. NGFI-A mRNA expression decreased with age in CA1, CA2 and neocortex. Long-term amitriptyline treatment, which improved spatial learning in young rats, had no significant effects on NGFI-A mRNA levels. Whether hippocampal NGFI-A plays a direct role in the mechanism of learning and memory remains to be determined.

Original languageEnglish
Pages (from-to)354-357
Number of pages4
JournalMolecular brain research
Issue number2
Publication statusPublished - Dec 1996

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