Definition and classification of cancer cachexia: an international consensus

Kenneth Fearon; Florian Strasser; Stefan D Anker; Ingvar Bosaeus; Eduardo Bruera; Robin L Fainsinger; Aminah Jatoi; Charles Loprinzi; Neil MacDonald; Giovanni Mantovani; Mellar Davis; Maurizio Muscaritoli; Faith Ottery; Lukas Radbruch; Paula Ravasco; Declan Walsh; Andrew Wilcock; Stein Kaasa; Vickie E Baracos

doi:10.1016/S1470-2045(10)70218-7

Definition and classification of cancer cachexia: an international consensus

Kenneth Fearon, Florian Strasser, Stefan D Anker, Ingvar Bosaeus, Eduardo Bruera, Robin L Fainsinger, Aminah Jatoi, Charles Loprinzi, Neil MacDonald, Giovanni Mantovani, Mellar Davis, Maurizio Muscaritoli, Faith Ottery, Lukas Radbruch, Paula Ravasco, Declan Walsh, Andrew Wilcock, Stein Kaasa, Vickie E Baracos

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

To develop a framework for the definition and classification of cancer cachexia a panel of experts participated in a formal consensus process, including focus groups and two Delphi rounds. Cancer cachexia was defined as a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Its pathophysiology is characterised by a negative protein and energy balance driven by a variable combination of reduced food intake and abnormal metabolism. The agreed diagnostic criterion for cachexia was weight loss greater than 5%, or weight loss greater than 2% in individuals already showing depletion according to current bodyweight and height (body-mass index [BMI]

Original language	English
Pages (from-to)	489-95
Number of pages	7
Journal	The Lancet Oncology
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/S1470-2045(10)70218-7
Publication status	Published - 2011

Keywords / Materials (for Non-textual outputs)

Anorexia
Cachexia
Consensus
Delphi Technique
Energy Intake
Energy Metabolism
Expert Testimony
Focus Groups
Humans
International Cooperation
Muscle Strength
Muscle, Skeletal
Neoplasms
Sarcopenia
Severity of Illness Index
Syndrome
Weight Loss

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10.1016/S1470-2045(10)70218-7

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Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I., Bruera, E., Fainsinger, R. L., Jatoi, A., Loprinzi, C., MacDonald, N., Mantovani, G., Davis, M., Muscaritoli, M., Ottery, F., Radbruch, L., Ravasco, P., Walsh, D., Wilcock, A., Kaasa, S., & Baracos, V. E. (2011). Definition and classification of cancer cachexia: an international consensus. The Lancet Oncology, 12(5), 489-95. https://doi.org/10.1016/S1470-2045(10)70218-7

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title = "Definition and classification of cancer cachexia: an international consensus",

abstract = "To develop a framework for the definition and classification of cancer cachexia a panel of experts participated in a formal consensus process, including focus groups and two Delphi rounds. Cancer cachexia was defined as a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Its pathophysiology is characterised by a negative protein and energy balance driven by a variable combination of reduced food intake and abnormal metabolism. The agreed diagnostic criterion for cachexia was weight loss greater than 5%, or weight loss greater than 2% in individuals already showing depletion according to current bodyweight and height (body-mass index [BMI] ",

keywords = "Anorexia, Cachexia, Consensus, Delphi Technique, Energy Intake, Energy Metabolism, Expert Testimony, Focus Groups, Humans, International Cooperation, Muscle Strength, Muscle, Skeletal, Neoplasms, Sarcopenia, Severity of Illness Index, Syndrome, Weight Loss",

author = "Kenneth Fearon and Florian Strasser and Anker, {Stefan D} and Ingvar Bosaeus and Eduardo Bruera and Fainsinger, {Robin L} and Aminah Jatoi and Charles Loprinzi and Neil MacDonald and Giovanni Mantovani and Mellar Davis and Maurizio Muscaritoli and Faith Ottery and Lukas Radbruch and Paula Ravasco and Declan Walsh and Andrew Wilcock and Stein Kaasa and Baracos, {Vickie E}",

year = "2011",

doi = "10.1016/S1470-2045(10)70218-7",

language = "English",

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pages = "489--95",

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Fearon, K, Strasser, F, Anker, SD, Bosaeus, I, Bruera, E, Fainsinger, RL, Jatoi, A, Loprinzi, C, MacDonald, N, Mantovani, G, Davis, M, Muscaritoli, M, Ottery, F, Radbruch, L, Ravasco, P, Walsh, D, Wilcock, A, Kaasa, S & Baracos, VE 2011, 'Definition and classification of cancer cachexia: an international consensus', The Lancet Oncology, vol. 12, no. 5, pp. 489-95. https://doi.org/10.1016/S1470-2045(10)70218-7

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AU - Fearon, Kenneth

AU - Strasser, Florian

AU - Anker, Stefan D

AU - Bosaeus, Ingvar

AU - Bruera, Eduardo

AU - Fainsinger, Robin L

AU - Jatoi, Aminah

AU - Loprinzi, Charles

AU - MacDonald, Neil

AU - Mantovani, Giovanni

AU - Davis, Mellar

AU - Muscaritoli, Maurizio

AU - Ottery, Faith

AU - Radbruch, Lukas

AU - Ravasco, Paula

AU - Walsh, Declan

AU - Wilcock, Andrew

AU - Kaasa, Stein

AU - Baracos, Vickie E

PY - 2011

Y1 - 2011

N2 - To develop a framework for the definition and classification of cancer cachexia a panel of experts participated in a formal consensus process, including focus groups and two Delphi rounds. Cancer cachexia was defined as a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Its pathophysiology is characterised by a negative protein and energy balance driven by a variable combination of reduced food intake and abnormal metabolism. The agreed diagnostic criterion for cachexia was weight loss greater than 5%, or weight loss greater than 2% in individuals already showing depletion according to current bodyweight and height (body-mass index [BMI]

AB - To develop a framework for the definition and classification of cancer cachexia a panel of experts participated in a formal consensus process, including focus groups and two Delphi rounds. Cancer cachexia was defined as a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Its pathophysiology is characterised by a negative protein and energy balance driven by a variable combination of reduced food intake and abnormal metabolism. The agreed diagnostic criterion for cachexia was weight loss greater than 5%, or weight loss greater than 2% in individuals already showing depletion according to current bodyweight and height (body-mass index [BMI]

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KW - Cachexia

KW - Consensus

KW - Delphi Technique

KW - Energy Intake

KW - Energy Metabolism

KW - Expert Testimony

KW - Focus Groups

KW - Humans

KW - International Cooperation

KW - Muscle Strength

KW - Muscle, Skeletal

KW - Neoplasms

KW - Sarcopenia

KW - Severity of Illness Index

KW - Syndrome

KW - Weight Loss

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DO - 10.1016/S1470-2045(10)70218-7

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SN - 1474-5488

VL - 12

SP - 489

EP - 495

JO - The Lancet Oncology

JF - The Lancet Oncology

IS - 5

ER -

Definition and classification of cancer cachexia: an international consensus

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Keywords / Materials (for Non-textual outputs)

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