DegrAAAded into silence

Research output: Contribution to journalEditorialpeer-review

Abstract / Description of output

In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Buhler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.

Original languageEnglish
Pages (from-to)651-653
Number of pages3
JournalCell
Volume129
Issue number4
DOIs
Publication statusPublished - 18 May 2007

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