DegrAAAded into silence

Elizabeth H. Bayne; Sharon A. White; Robin C. Allshire

doi:10.1016/j.cell.2007.05.004

DegrAAAded into silence

Elizabeth H. Bayne, Sharon A. White, Robin C. Allshire

School of Biological Sciences

Research output: Contribution to journal › Editorial › peer-review

Abstract

In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Buhler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.

Original language	English
Pages (from-to)	651-653
Number of pages	3
Journal	Cell
Volume	129
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2007.05.004
Publication status	Published - 18 May 2007

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@article{78daac3060e54e298666b93cc2fadfab,

title = "DegrAAAded into silence",

abstract = "In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Buhler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.",

author = "Bayne, {Elizabeth H.} and White, {Sharon A.} and Allshire, {Robin C.}",

year = "2007",

month = may,

day = "18",

doi = "10.1016/j.cell.2007.05.004",

language = "English",

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journal = "Cell",

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T1 - DegrAAAded into silence

AU - Bayne, Elizabeth H.

AU - White, Sharon A.

AU - Allshire, Robin C.

PY - 2007/5/18

Y1 - 2007/5/18

N2 - In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Buhler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.

AB - In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Buhler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.

U2 - 10.1016/j.cell.2007.05.004

DO - 10.1016/j.cell.2007.05.004

M3 - Editorial

VL - 129

SP - 651

EP - 653

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -

DegrAAAded into silence

Abstract

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