Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model

Cornelia McLean; Jane Sterling; Justine  Mowat; Anthony Nash; Margaret A Stanley

doi:10.1099/0022-1317-74-2-239

Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model

Cornelia McLean, Jane Sterling, Justine Mowat, Anthony Nash, Margaret A Stanley

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto syngeneic mice to form a differentiated epithelium, thus closely mimicking the natural infection. A delayed-type hypersensitivity response could be demonstrated after intradermal challenge with a vaccinia virus recombinant expressing the E7 protein. This response appeared to be specific for the E7 polypeptide and was mediated by CD4+ cells.

Original language	English
Pages (from-to)	239-45
Number of pages	7
Journal	Journal of General Virology
Volume	74
Issue number	2
DOIs	https://doi.org/10.1099/0022-1317-74-2-239
Publication status	Published - Feb 1993

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title = "Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model",

abstract = "To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto syngeneic mice to form a differentiated epithelium, thus closely mimicking the natural infection. A delayed-type hypersensitivity response could be demonstrated after intradermal challenge with a vaccinia virus recombinant expressing the E7 protein. This response appeared to be specific for the E7 polypeptide and was mediated by CD4+ cells.",

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AU - Stanley, Margaret A

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AB - To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto syngeneic mice to form a differentiated epithelium, thus closely mimicking the natural infection. A delayed-type hypersensitivity response could be demonstrated after intradermal challenge with a vaccinia virus recombinant expressing the E7 protein. This response appeared to be specific for the E7 polypeptide and was mediated by CD4+ cells.

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Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model

Abstract

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