Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

Simon A Babayan; Honglin Luo; Nick Gray; David W Taylor; Judith E Allen

doi:10.1371/journal.pntd.0001968

Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

Simon A Babayan, Honglin Luo, Nick Gray, David W Taylor, Judith E Allen

Research output: Contribution to journal › Article › peer-review

Abstract

Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on its capacity to counter parasite-driven immunomodulation.

Original language	English
Article number	e1968
Number of pages	11
Journal	PLoS Neglected Tropical Diseases
Volume	6
Issue number	12
DOIs	https://doi.org/10.1371/journal.pntd.0001968
Publication status	Published - 2012

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Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

Abstract

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