Deletion of Pten of CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies

Alexander Medvinsky, David Hills, Cristina Mirantes, Maria Alba Dosil

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Since its discovery in the late 90s, Pten has turned out to be one of the most important tumor suppressor genes. Pten loss results in increased activation of PI3K/Akt signaling pathway, which is associated with increased proliferation, survival and neoplastic growth. Here, we have addressed the effects of conditional deletion of Pten in hematopoietic cells by crossing Pten conditional knock-out mice with a knock-in mouse expressing the Cre recombinase in the CD45 locus. CD45 is also known as Leucocyte Common Antigen and it is expressed in virtually all white cells as well as in hematopoietic stem cells. Using a reporter mouse, we demonstrate that CD45-Cre mouse displays recombinase activity in both myeloid and lymphoid cells. However, deletion of Pten in CD45 expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies.
Original languageEnglish
Pages (from-to)1907-1911
JournalBlood
Volume127
Issue number5
Early online date14 Jan 2016
DOIs
Publication statusPublished - 14 Apr 2016

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