Delirium and Cerebrospinal Fluid S100B in Hip Fracture Patients: A Preliminary Study

Roanna J Hall; Karen J Ferguson; Mary Andrews; Alison J E Green; Tim O White; Ian R Armstrong; Alasdair M J Maclullich

doi:10.1016/j.jagp.2012.12.024

Delirium and Cerebrospinal Fluid S100B in Hip Fracture Patients: A Preliminary Study

Roanna J Hall, Karen J Ferguson, Mary Andrews, Alison J E Green, Tim O White, Ian R Armstrong, Alasdair M J Maclullich

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives
Delirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid (CSF) S100B.

Methods
Forty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre- and post-operatively. CSF S100B levels were measured in samples collected at the onset of surgery.

Results
Participants with pre-operative delirium (N = 8) had elevated Log10 CSF S100B (mean: -0.156; SD: 0.238) compared with those without delirium (mean: -0.306; SD: 0.162), Student's t-test t = 2.18, df = 43, p = 0.035.

Conclusions
This study provides preliminary evidence of elevated CSF S100B in current delirium, consistent with findings in serum and with other studies showing elevated S100B in the presence of diverse forms of CNS injury.

Original language	English
Journal	American Journal of Geriatric Psychiatry
Early online date	18 Apr 2013
DOIs	https://doi.org/10.1016/j.jagp.2012.12.024
Publication status	Published - 2013

Keywords / Materials (for Non-textual outputs)

Delirium
S100B
cerebrospinal fluid

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10.1016/j.jagp.2012.12.024

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@article{5142326d190a4667bcad280c65518c14,

title = "Delirium and Cerebrospinal Fluid S100B in Hip Fracture Patients: A Preliminary Study",

abstract = "ObjectivesDelirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid (CSF) S100B.MethodsForty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre- and post-operatively. CSF S100B levels were measured in samples collected at the onset of surgery. ResultsParticipants with pre-operative delirium (N = 8) had elevated Log10 CSF S100B (mean: -0.156; SD: 0.238) compared with those without delirium (mean: -0.306; SD: 0.162), Student's t-test t = 2.18, df = 43, p = 0.035. ConclusionsThis study provides preliminary evidence of elevated CSF S100B in current delirium, consistent with findings in serum and with other studies showing elevated S100B in the presence of diverse forms of CNS injury.",

keywords = "Delirium, S100B, cerebrospinal fluid",

author = "Hall, {Roanna J} and Ferguson, {Karen J} and Mary Andrews and Green, {Alison J E} and White, {Tim O} and Armstrong, {Ian R} and Maclullich, {Alasdair M J}",

note = "MRC-funded",

year = "2013",

doi = "10.1016/j.jagp.2012.12.024",

language = "English",

journal = "American Journal of Geriatric Psychiatry",

issn = "1064-7481",

publisher = "Elsevier",

}

TY - JOUR

T1 - Delirium and Cerebrospinal Fluid S100B in Hip Fracture Patients

T2 - A Preliminary Study

AU - Hall, Roanna J

AU - Ferguson, Karen J

AU - Andrews, Mary

AU - Green, Alison J E

AU - White, Tim O

AU - Armstrong, Ian R

AU - Maclullich, Alasdair M J

N1 - MRC-funded

PY - 2013

Y1 - 2013

N2 - ObjectivesDelirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid (CSF) S100B.MethodsForty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre- and post-operatively. CSF S100B levels were measured in samples collected at the onset of surgery. ResultsParticipants with pre-operative delirium (N = 8) had elevated Log10 CSF S100B (mean: -0.156; SD: 0.238) compared with those without delirium (mean: -0.306; SD: 0.162), Student's t-test t = 2.18, df = 43, p = 0.035. ConclusionsThis study provides preliminary evidence of elevated CSF S100B in current delirium, consistent with findings in serum and with other studies showing elevated S100B in the presence of diverse forms of CNS injury.

AB - ObjectivesDelirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid (CSF) S100B.MethodsForty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre- and post-operatively. CSF S100B levels were measured in samples collected at the onset of surgery. ResultsParticipants with pre-operative delirium (N = 8) had elevated Log10 CSF S100B (mean: -0.156; SD: 0.238) compared with those without delirium (mean: -0.306; SD: 0.162), Student's t-test t = 2.18, df = 43, p = 0.035. ConclusionsThis study provides preliminary evidence of elevated CSF S100B in current delirium, consistent with findings in serum and with other studies showing elevated S100B in the presence of diverse forms of CNS injury.

KW - Delirium

KW - S100B

KW - cerebrospinal fluid

U2 - 10.1016/j.jagp.2012.12.024

DO - 10.1016/j.jagp.2012.12.024

M3 - Article

C2 - 23602305

SN - 1064-7481

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

ER -

Delirium and Cerebrospinal Fluid S100B in Hip Fracture Patients: A Preliminary Study

Abstract

Keywords / Materials (for Non-textual outputs)

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