Dendritic cells in cattle: phenotype and function

Chris J Howard, Gareth P Brooke, Dirk Werling, Paul Sopp, Jayne Hope, K R Parsons, R A Collins

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Dendritic cells are professional antigen presenting cells derived from the bone marrow and distributed throughout body tissues where they are located in sites that are suitable for antigen uptake. They are central to the induction of immune responses in naive animals and thus have become targets in strategies that are aimed at modulating resistance to infection. Studies in cattle have shown that the dendritic cells are phenotypically heterogeneous and that the different phenotypes have different biological properties. The molecular basis for this variation has begun to be investigated and has led to the identification of a member of the SIRPalpha family of signal regulatory proteins (MyD1) on a subset of dendritic cells in afferent lymph. Uptake of antigen by cattle dendritic cells is by a number of mechanisms that can involve endocytosis via clathrin coated pits or via caveolae as well as macropinocytosis.
Original languageEnglish
Pages (from-to)119-24
Number of pages6
JournalVeterinary Immunology and Immunopathology
Volume72
Issue number1-2
Publication statusPublished - 15 Dec 1999

Keywords

  • Animals
  • Cattle/immunology
  • Clathrin/immunology
  • Dendritic Cells/classification
  • Dendritic Cells/immunology
  • Endocytosis/immunology
  • Immunophenotyping
  • Pinocytosis/immunology
  • Protein Sorting Signals/immunology

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