Dendritic peptide release and peptide-dependent behaviours

Mike Ludwig, Gareth Leng

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Neuropeptides that are released from dendrites, such as oxytocin and vasopressin, function as autocrine or paracrine signals at their site of origin, but can also act at distant brain targets to evoke long-lasting changes in behaviour. Oxytocin, for instance, has profound effects on social bonding that are exerted at sites that richly express oxytocin receptors, but which are innervated by few, if any, oxytocin-containing projections. How can a prolonged, diffuse signal have coherent behavioural consequences? The recently demonstrated ability of neuropeptides to prime vesicle stores for activity-dependent release could lead to a temporary functional reorganization of neuronal networks harbouring specific peptide receptors, providing a substrate for long-lasting effects.

Original languageEnglish
Pages (from-to)126-36
Number of pages11
JournalNature Reviews Neuroscience
Issue number2
Publication statusPublished - Feb 2006

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Autocrine Communication
  • Dendrites
  • Models, Neurological
  • Neurons
  • Neuropeptides
  • Oxytocin
  • Time Factors
  • Vasopressins


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