Dendritic release of vasopressin and oxytocin

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

In addition to the release of neurotransmitters from their axon terminals, several neuronal populations are able to release their products from their dendrites. The cell bodies and dendrites of vasopressin- and oxytocin-producing neurones are mainly located within the hypothalamic supraoptic and paraventricular nuclei and neuropeptide release within the magnocellular nuclei has been shown in vitro and in vivo. Local release is induced by a range of physiological and pharmacological stimuli, and is regulated by a number of brain areas; locally released peptides are mainly involved in pre- and postsynaptic modulation of the electrical activity of magnocellular neurones. Spatial and temporal differences between peptide release within the nuclei and that from the distant axonal varicosities indicate that the release mechanisms are at least partially independent, supporting the hypothesis of locally regulated dendritic release of vasopressin and oxytocin. In this respect, magnocellular neurones show similarities to other neuronal populations and thus autoregulation of neuronal activity by dendritic neuromodulator release may be a general phenomenon within the brain.

Original languageEnglish
Pages (from-to)881-95
Number of pages15
JournalJournal of Neuroendocrinology
Issue number12
Publication statusPublished - Dec 1998

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Dendrites
  • Female
  • Hypothalamus, Anterior
  • Lactation
  • Neurotransmitter Agents
  • Osmolar Concentration
  • Oxytocin
  • Pregnancy
  • Stress, Physiological
  • Synapses
  • Vasopressins


Dive into the research topics of 'Dendritic release of vasopressin and oxytocin'. Together they form a unique fingerprint.

Cite this