Dermcidin expression confers a survival advantage in prostate cancer cells subjected to oxidative stress or hypoxia

Grant D Stewart, Alastair G Lowrie, Antony C P Riddick, Kenneth C H Fearon, Fouad K Habib, James A Ross

Research output: Contribution to journalArticlepeer-review

Abstract

Dermcidin (DCD) is a candidate survival gene in breast cancer. DCD gene expression has been identified in prostate cancer cell lines and primary prostate cancer tissue. The DCD protein is composed of proteolysis-inducing factor-core peptide (PIF-CP) and the skin antimicrobial DCD-1. The aim of this work was to: (i) establish if the DCD gene confers resistance of prostate cancer cells to hypoxia and oxidative stress; (ii) identify the component of the gene transcript responsible for this effect.
Original languageEnglish
Pages (from-to)1308-17
Number of pages10
JournalProstate
Volume67
Issue number12
DOIs
Publication statusPublished - 2007

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