@inproceedings{a6482b63514d43b89f7a43f7164a5f93,
title = "Design and fabrication of microelectrodes for electrical impedance tomography of cell spheroids",
abstract = "Three-dimensional (3D) tumour spheroids exhibit great potential as an in vitro for pharmaceutical drug testing. Spheroids represent more physiologically relevant systems compared to 2D cell culture models. In this work, MCF7 spheroids are cultured in Corning{\textregistered} spheroid microplates to investigate cell morphology and proliferation. Platinum microelectrodes designed to enable electrical impedance tomography (EIT) imaging were fabricated on glass substrates. EIT measurements were performed on 250 μm radius circular electrode tips for 0.71 mm MCF7 spheroid at 20 kHz using time difference imaging method. Initial results indicate the capability of EIT to image cell spheroids.",
keywords = "biosensor, EIT, MCF7, microfabrication, spheroids culture",
author = "Nadira Jamil and Stewart Smith and Yunjie Yang and Jiabin Jia and Pierre Bagnaninchi and Eva Gonzalez-Fernandez",
note = "Acceptance date set to exclude from REF OA Policy; 2016 IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2016 ; Conference date: 04-12-2016 Through 08-12-2016",
year = "2017",
month = feb,
day = "6",
doi = "10.1109/IECBES.2016.7843486",
language = "English",
series = "IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences",
publisher = "Institute of Electrical and Electronics Engineers",
pages = "426--431",
booktitle = "IECBES 2016 - IEEE-EMBS Conference on Biomedical Engineering and Sciences",
}