TY - JOUR
T1 - Design and rationale of CURRENT-OASIS 7
T2 - a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy
AU - CURRENT-OASIS 7 Steering Committee
AU - Mehta, Shamir R
AU - Bassand, Jean-Pierre
AU - Chrolavicius, Susan
AU - Diaz, Rafael
AU - Fox, Keith A A
AU - Granger, Christopher B
AU - Jolly, Sanjit
AU - Rupprecht, Hans-Jurgen
AU - Widimsky, Petr
AU - Yusuf, Salim
PY - 2008/12
Y1 - 2008/12
N2 - Antiplatelet therapy with clopidogrel and acetylsalicylic acid (ASA) reduces major cardiovascular events in patients with ST and non-ST-segment-elevation acute coronary syndromes (ACS). Recent mechanistic and clinical data suggest that higher loading and maintenance doses of clopidogrel may achieve a more rapid and greater degree of platelet inhibition that translates into improved clinical outcomes, but this is yet to be formally evaluated in an adequately powered randomized trial.
AB - Antiplatelet therapy with clopidogrel and acetylsalicylic acid (ASA) reduces major cardiovascular events in patients with ST and non-ST-segment-elevation acute coronary syndromes (ACS). Recent mechanistic and clinical data suggest that higher loading and maintenance doses of clopidogrel may achieve a more rapid and greater degree of platelet inhibition that translates into improved clinical outcomes, but this is yet to be formally evaluated in an adequately powered randomized trial.
UR - http://www.scopus.com/inward/record.url?scp=56949093392&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2008.07.026
DO - 10.1016/j.ahj.2008.07.026
M3 - Article
C2 - 19033002
VL - 156
SP - 1080
EP - 1088
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 6
ER -