Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes

Antoine Claessens, Ashfaq Ghumra, Archna P Gupta, Sachel Mok, Zbynek Bozdech, J Alexandra Rowe

Research output: Contribution to journalArticlepeer-review

Abstract

The cytoadherence of Plasmodium falciparum is thought to be mediated by variant surface antigens (VSA), encoded by var, rif, stevor and pfmc-2tm genes. The last three families have rarely been studied in the context of cytoadherence. As most VSA genes are unique, the variability among sequences has impeded the functional study of VSA across different P. falciparum strains. However, many P. falciparum genomes have recently been sequenced, allowing the development of specific microarray probes for each VSA gene.
Original languageEnglish
Number of pages16
JournalMalaria Journal
Volume10
Issue number180
DOIs
Publication statusPublished - 2011

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