Design of robust metabolic pathways

Renato Umeton*, Giovanni Stracquadanio, Anilkumar Sorathiya, Alessio Papini, Pietro Liò, Giuseppe Nicosia

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss Pareto-Front as an estimator of robust metabolic pathways.

Original languageEnglish
Title of host publication2011 48th ACM/EDAC/IEEE Design Automation Conference, DAC 2011
Pages747-752
Number of pages6
Publication statusPublished - 16 Sep 2011
Event2011 48th ACM/EDAC/IEEE Design Automation Conference, DAC 2011 - San Diego, CA, United States
Duration: 5 Jun 20119 Jun 2011

Conference

Conference2011 48th ACM/EDAC/IEEE Design Automation Conference, DAC 2011
CountryUnited States
CitySan Diego, CA
Period5/06/119/06/11

Keywords

  • Carbon metabolism
  • Geobacter sulfurreducens
  • Metabolic engineering
  • Multi-objective Optimization
  • Mutational Robustness

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