Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques.: Tissue and Cell Engineering Society (TCES) 2015: 19-21 July 2015 at Southampton Ref: European Cells and Materials Vol. 29. Suppl. 3, 2015 (page 111)

Tianhao Zhou; Edward McCarthy; Constantinos Soutis; Sarah H. Cartmell

Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques. Tissue and Cell Engineering Society (TCES) 2015: 19-21 July 2015 at Southampton Ref: European Cells and Materials Vol. 29. Suppl. 3, 2015 (page 111)

Tianhao Zhou, Edward McCarthy, Constantinos Soutis, Sarah H. Cartmell

School of Engineering

Research output: Contribution to conference › Poster › peer-review

Abstract / Description of output

The physical and chemical properties of a scaffold greatly influence a cell’s bio-activity. By chemically synthesising the materials of a scaffold, one can better simulate the natural extracellular environment to provide optimum conditions for cell adhesion and differentiation. Herein, we employ in-situ polymerisation to produce various 3D polylactone acid ionomer cell-scaffold structures using Mg/Al layered-double-hydroxide (CO32-) as the initiator using the method first published by McCarthy et al1. The key product of this reaction is a polymer-based ionomer complex that is insoluble in methylene chloride and has a pore-morphology that enables its use as a biodegradable scaffold for osteoblasts.

Original language	English
Pages	111
Number of pages	1
Publication status	Published - 21 Sept 2015

Keywords / Materials (for Non-textual outputs)

artificial cell growth
polylactic acid
polylactone
ring opening polymerisation
ionomer
polymer
materials characterisation
material chemistry

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Zhou et al. TCES 2015_FinalAccepted author manuscript, 319 KBLicence: Creative Commons: Attribution (CC-BY)

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title = "Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques.: Tissue and Cell Engineering Society (TCES) 2015: 19-21 July 2015 at Southampton Ref: European Cells and Materials Vol. 29. Suppl. 3, 2015 (page 111) ",

abstract = "The physical and chemical properties of a scaffold greatly influence a cell{\textquoteright}s bio-activity. By chemically synthesising the materials of a scaffold, one can better simulate the natural extracellular environment to provide optimum conditions for cell adhesion and differentiation. Herein, we employ in-situ polymerisation to produce various 3D polylactone acid ionomer cell-scaffold structures using Mg/Al layered-double-hydroxide (CO32-) as the initiator using the method first published by McCarthy et al1. The key product of this reaction is a polymer-based ionomer complex that is insoluble in methylene chloride and has a pore-morphology that enables its use as a biodegradable scaffold for osteoblasts.",

keywords = "artificial cell growth, polylactic acid , polylactone, ring opening polymerisation, ionomer, polymer, materials characterisation, material chemistry",

author = "Tianhao Zhou and Edward McCarthy and Constantinos Soutis and Cartmell, {Sarah H.}",

note = "Full reference: Tissue and Cell Engineering Society (TCES) 2015: 19-21 July 2015 at Southampton Ref: European Cells and Materials Vol. 29. Suppl. 3, 2015 (page 111) Title: Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques. ",

year = "2015",

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}

Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques. Tissue and Cell Engineering Society (TCES) 2015: 19-21 July 2015 at Southampton Ref: European Cells and Materials Vol. 29. Suppl. 3, 2015 (page 111) . / Zhou, Tianhao; McCarthy, Edward; Soutis, Constantinos et al.
2015. 111.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques.

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AU - Zhou, Tianhao

AU - McCarthy, Edward

AU - Soutis, Constantinos

AU - Cartmell, Sarah H.

N1 - Full reference: Tissue and Cell Engineering Society (TCES) 2015: 19-21 July 2015 at Southampton Ref: European Cells and Materials Vol. 29. Suppl. 3, 2015 (page 111) Title: Design of scaffold morphology for optical cell differentiation using novel polymerisation techniques.

PY - 2015/9/21

Y1 - 2015/9/21

N2 - The physical and chemical properties of a scaffold greatly influence a cell’s bio-activity. By chemically synthesising the materials of a scaffold, one can better simulate the natural extracellular environment to provide optimum conditions for cell adhesion and differentiation. Herein, we employ in-situ polymerisation to produce various 3D polylactone acid ionomer cell-scaffold structures using Mg/Al layered-double-hydroxide (CO32-) as the initiator using the method first published by McCarthy et al1. The key product of this reaction is a polymer-based ionomer complex that is insoluble in methylene chloride and has a pore-morphology that enables its use as a biodegradable scaffold for osteoblasts.

AB - The physical and chemical properties of a scaffold greatly influence a cell’s bio-activity. By chemically synthesising the materials of a scaffold, one can better simulate the natural extracellular environment to provide optimum conditions for cell adhesion and differentiation. Herein, we employ in-situ polymerisation to produce various 3D polylactone acid ionomer cell-scaffold structures using Mg/Al layered-double-hydroxide (CO32-) as the initiator using the method first published by McCarthy et al1. The key product of this reaction is a polymer-based ionomer complex that is insoluble in methylene chloride and has a pore-morphology that enables its use as a biodegradable scaffold for osteoblasts.

KW - artificial cell growth

KW - polylactic acid

KW - polylactone

KW - ring opening polymerisation

KW - ionomer

KW - polymer

KW - materials characterisation

KW - material chemistry

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