Design Space Investigation for Development of Continuous Flow Syntheses of Active Pharmaceutical Ingredients

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Continuous flow chemistry and synthesis have received significant attention over the past two decades for their potential for enhancing yields, selectivities, productivities, smaller operation and implementation of otherwise difficult/dangerous reactions. Recent demonstrations applied to a variety of different reaction types have highlighted the potential for continuous manufacturing technologies for fine and speciality chemical production, including many critical Active Pharmaceutical Ingredients (APIs) but also many biopharmaceuticals and therapeutics. This study discusses recent demonstrations from the literature on design space elucidation for continuous API production and further highlights attainable regions of recoveries, material efficiencies, flowsheet complexity and cost components for upstream (reaction + separation) via modelling, simulation and nonlinear optimisation studies, providing insight into optimal regions of operation.
Original languageEnglish
Title of host publicationComputer Aided Chemical Engineering
Subtitle of host publication30th European Symposium on Computer Aided Process Engineering
EditorsSauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano, Davide Manca
PublisherElsevier
Pages961-966
Number of pages6
Volume48
ISBN (Print)1570-7946
DOIs
Publication statusPublished - 19 Oct 2020
Event30th European Symposium on Computer Aided Process Engineering - Online, Milan, Italy
Duration: 31 Aug 20202 Sep 2020
https://www.aidic.it/escape30/enter.php

Publication series

NameComputer Aided Chemical Engineering
PublisherElsevier
Volume48
ISSN (Print)1570-7946

Conference

Conference30th European Symposium on Computer Aided Process Engineering
Abbreviated titleESCAPE 30
Country/TerritoryItaly
CityMilan
Period31/08/202/09/20
Internet address

Keywords

  • Continuous flow synthesis
  • Active Pharmaceutical Ingredients (APIs)
  • pharmaceutical manufacturing
  • design space investigation
  • comparative evaluation

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