Abstract / Description of output
Recent findings suggest that treatment with 11β-HSD1 inhibitors provides a novel approach to deal with age-related cognitive dysfunctions, including Alzheimer's disease. In this work we report potent 11β-HSD1 inhibitors featuring unexplored pyrrolidine-based polycyclic substituents. A selected candidate administered to 12-month-old SAMP8 mice for four weeks prevented memory deficits and displayed a neuroprotective action. This is the first time that 11β-HSD1 inhibitors have been studied in this broadly-used mouse model of accelerated senescence and late-onset Alzheimer's disease.
Original language | English |
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Pages (from-to) | 412-428 |
Number of pages | 17 |
Journal | European Journal of Medicinal Chemistry |
Volume | 139 |
Early online date | 4 Aug 2017 |
DOIs | |
Publication status | E-pub ahead of print - 4 Aug 2017 |
Keywords / Materials (for Non-textual outputs)
- Journal Article