Designing pdms-based microfluidics for the production of surfactant-free giant lipid vesicles

Naresh Yandrapalli, Tom Robinson*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

Developing methods to produce biomimetic lipid-based vesicles is a logical step towards understanding biomembranes and even to realize the bottom-up construction of artificial cells. In this paper, we present our developments using PDMS-based microfluidics for the production of giant unilamellar vesicles (GUVs). Not only do we have a working design that can consistently produce GUVs of specific size, but our design avoids usage of unwanted surfactants or additives such as block co-polymers, poly-vinyl alcohol, and glycerol. Overall, our work represents a major advancement for high-throughput production of lipid-based vesicles.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages362-363
Number of pages2
Volume1
ISBN (Electronic)9781733419000
ISBN (Print)9781713818526
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords / Materials (for Non-textual outputs)

  • Double emulsion
  • Giant lipid vesicles
  • High-throughput
  • Surfactant-free

Fingerprint

Dive into the research topics of 'Designing pdms-based microfluidics for the production of surfactant-free giant lipid vesicles'. Together they form a unique fingerprint.

Cite this