Designing stapled peptides to inhibit protein-protein interactions: An analysis of successes in a rapidly changing field

Marie T.J. Bluntzer, James O'Connell, Terry S. Baker, Julien Michel, Alison N. Hulme*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Two decades after their discovery, stapled peptide methodologies have evolved to a point where they can be used with confidence to generate therapeutic leads. Research groups across the world are testing innovative methodologies for their design, with dozens of publications released every month. A number of stapled peptide drug candidates have recently entered clinical trials. In this review, we provide an overview of successful methods for their construction, highlight trends in the deposited crystal structures of stapled peptide complexed to their targets and discuss properties that contribute towards improved pharmacological profiles.

Original languageEnglish
JournalPeptide Science
Early online date12 Oct 2020
DOIs
Publication statusE-pub ahead of print - 12 Oct 2020

Keywords

  • analysis
  • crystal structure
  • design
  • stapled peptides
  • therapeutics

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