Projects per year
Abstract
Synthetic biology is challenged by the complexity and the unpredictability of living systems. While one response to this complexity involves simplifying cells to create more fully specified systems, another approach utilizes directed evolution, releasing some control and using unpredictable change to achieve design goals. Here we discuss SCRaMbLE, employed in the synthetic yeast project, as an example of synthetic biology design through working with living systems. SCRaMbLE is a designed tool without being a design tool, harnessing the activities of the yeast rather than relying entirely on scientists' deliberate choices. We suggest that directed evolution at the level of the whole organism allows scientists and microorganisms to "collaborate" to achieve design goals, suggesting new directions for synthetic biology.
Original language | English |
---|---|
Pages (from-to) | 2950 |
Journal | Nature Communications |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - 27 Jul 2018 |
Fingerprint
Dive into the research topics of 'Designing with living systems in the synthetic yeast project'. Together they form a unique fingerprint.Projects
- 3 Finished
-
14-ERASynBio-IESY-Inducible Evolution of Synthetic Yeast genomes
Cai, Y.
1/01/15 → 31/12/17
Project: Research
-
14 ERASynBio - IESY - Inducible Evolution of Synthetic Yeast genomes
Calvert, J. & Frow, E.
1/01/15 → 31/12/17
Project: Research
-
ENLIFE: Engineering Life: ideas, practices, promises and policies
Calvert, J. & Schyfter Camacho, P.
1/09/14 → 28/02/19
Project: Research
Profiles
-
Jane Calvert
- School of Social and Political Science - Personal Chair of Science and Technology Studies
- SynthSys
- Global Health Academy
Person: Academic: Research Active