Detection of a novel DNA virus (TTV) in blood donors and blood products

P Simmonds; F Davidson; C Lycett; L E Prescott; D M MacDonald; J Ellender; P L Yap; C A Ludlam; G H Haydon; J Gillon; L M Jarvis

doi:10.1016/S0140-6736(98)03056-6

Detection of a novel DNA virus (TTV) in blood donors and blood products

P Simmonds, F Davidson, C Lycett, L E Prescott, D M MacDonald, J Ellender, P L Yap, C A Ludlam, G H Haydon, J Gillon, L M Jarvis

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

A newly discovered DNA virus, transfusion-transmitted virus (TTV), has been implicated as a cause of post-transfusion hepatitis. We investigated the frequency of TTV viraemia in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and IX clotting factors. We also investigated the possible aetiological role of TTV in cryptogenic fulminant hepatic failure (FHF).

Original language	English
Pages (from-to)	191-195
Number of pages	5
Journal	The Lancet
Volume	352
Issue number	9123
DOIs	https://doi.org/10.1016/S0140-6736(98)03056-6
Publication status	Published - 18 Jul 1998

Keywords / Materials (for Non-textual outputs)

Adult
Aged
Blood Component Transfusion
Blood Donors
Child
DNA Viruses
Female
Great Britain
Hemophilia A
Hepatic Encephalopathy
Hepatitis, Viral, Human
Humans
Japan
Male
Middle Aged
Polymerase Chain Reaction
Viremia

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10.1016/S0140-6736(98)03056-6

Cite this

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title = "Detection of a novel DNA virus (TTV) in blood donors and blood products",

abstract = "A newly discovered DNA virus, transfusion-transmitted virus (TTV), has been implicated as a cause of post-transfusion hepatitis. We investigated the frequency of TTV viraemia in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and IX clotting factors. We also investigated the possible aetiological role of TTV in cryptogenic fulminant hepatic failure (FHF).",

keywords = "Adult, Aged, Blood Component Transfusion, Blood Donors, Child, DNA Viruses, Female, Great Britain, Hemophilia A, Hepatic Encephalopathy, Hepatitis, Viral, Human, Humans, Japan, Male, Middle Aged, Polymerase Chain Reaction, Viremia",

author = "P Simmonds and F Davidson and C Lycett and Prescott, {L E} and MacDonald, {D M} and J Ellender and Yap, {P L} and Ludlam, {C A} and Haydon, {G H} and J Gillon and Jarvis, {L M}",

year = "1998",

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doi = "10.1016/S0140-6736(98)03056-6",

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TY - JOUR

T1 - Detection of a novel DNA virus (TTV) in blood donors and blood products

AU - Simmonds, P

AU - Davidson, F

AU - Lycett, C

AU - Prescott, L E

AU - MacDonald, D M

AU - Ellender, J

AU - Yap, P L

AU - Ludlam, C A

AU - Haydon, G H

AU - Gillon, J

AU - Jarvis, L M

PY - 1998/7/18

Y1 - 1998/7/18

N2 - A newly discovered DNA virus, transfusion-transmitted virus (TTV), has been implicated as a cause of post-transfusion hepatitis. We investigated the frequency of TTV viraemia in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and IX clotting factors. We also investigated the possible aetiological role of TTV in cryptogenic fulminant hepatic failure (FHF).

AB - A newly discovered DNA virus, transfusion-transmitted virus (TTV), has been implicated as a cause of post-transfusion hepatitis. We investigated the frequency of TTV viraemia in UK blood donors, and the extent to which TTV contaminates blood products such as factor VIII and IX clotting factors. We also investigated the possible aetiological role of TTV in cryptogenic fulminant hepatic failure (FHF).

KW - Adult

KW - Aged

KW - Blood Component Transfusion

KW - Blood Donors

KW - Child

KW - DNA Viruses

KW - Female

KW - Great Britain

KW - Hemophilia A

KW - Hepatic Encephalopathy

KW - Hepatitis, Viral, Human

KW - Humans

KW - Japan

KW - Male

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Viremia

U2 - 10.1016/S0140-6736(98)03056-6

DO - 10.1016/S0140-6736(98)03056-6

M3 - Article

C2 - 9683208

SN - 0140-6736

VL - 352

SP - 191

EP - 195

JO - The Lancet

JF - The Lancet

IS - 9123

ER -

Detection of a novel DNA virus (TTV) in blood donors and blood products

Abstract

Keywords / Materials (for Non-textual outputs)

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