Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury

Toru Usui, Paul Whitaker, Xiaoli Meng, John Watson, Daniel Antoine, Neil S French, B. Kevin Park , Dean J Naisbitt

Research output: Contribution to journalArticlepeer-review

Abstract

Antituberculosis (TB) drug exposure is associated with a mild elevation of liver enzymes that occasionally develops into severe liver injury. Herein, we identify ethambutol- and rifampicin-specific CD4+ and CD8+ T-cell clones in a patient with fatal anti TB-related liver injury. The clones were activated to proliferate and secrete IFN-γ, Il-13, and granzyme B following drug treatment. Drug-responsive T-cells may contribute to the pathogenesis of antituberculosis-related liver failure.

Original languageEnglish
Pages (from-to)1793-1795
Number of pages3
JournalChemical research in toxicology
Volume29
Issue number11
Early online date4 Nov 2016
DOIs
Publication statusPublished - 21 Nov 2016

Keywords

  • Antitubercular Agents
  • Chemical and Drug Induced Liver Injury
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • T-Lymphocytes
  • Tuberculosis, Pulmonary
  • Case Reports
  • Journal Article
  • Research Support, Non-U.S. Gov't

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