Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water: a potential role for water in the environmental dissemination

M Concepción Porrero, Ewan M Harrison, José Francisco Fernández-Garayzábal, Gavin K Paterson, Alberto Díez-Guerrier, Mark A Holmes, Lucas Domínguez

Research output: Contribution to journalArticlepeer-review

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a public health concern due to limited treatment options. The recent description of a mecA homologue, mecC in human and cattle, led to studies to detect this new variant in human and other animal species. Detection of mecC in wild boar and fallow deer in a Spanish game estate led us to further investigate the presence of mecC-MRSA at this location. Samples from cattle, wild animals, workers and river water were tested. A further three mecC-MRSA isolates were obtained from river water. Molecular characterization (multilocus sequence typing and spa typing) and antimicrobial susceptibility testing (broth microdilution) showed that isolates were similar to those detected in wild animals. Whole genome sequencing confirmed that the isolates from the river water and wild animals in the same geographic area were all closely related isolates of ST425 mecC-MRSA. The presence of mecC-MRSA in the river water highlights the potential role of water in the dissemination of mecC-MRSA.

Original languageEnglish
Pages (from-to)705-8
Number of pages4
JournalEnvironmental microbiology reports
Volume6
Issue number6
Publication statusPublished - Dec 2014

Keywords

  • Animals
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Cattle
  • Humans
  • Methicillin-Resistant Staphylococcus aureus
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Phylogeny
  • Rivers
  • Journal Article
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water: a potential role for water in the environmental dissemination'. Together they form a unique fingerprint.

Cite this