@article{7eab2311cf2642639acffc648c5e2ba8,
title = "Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020",
abstract = "Background: The progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study of blood donors in Scotland in the spring of 2020 to detect neutralising antibodies to SARS-CoV-2 as a marker of past infection and epidemic progression. Aim: Our objective was to determine if sera from blood bank donors can be used to track the emergence and progression of the SARS-CoV-2 epidemic. Methods: A pseudotyped SARS-CoV-2 virus microneutralisation assay was used to detect neutralising antibodies to SARS-CoV-2. The study comprised samples from 3,500 blood donors collected in Scotland between 17 March and 18 May 2020. Controls were collected from 100 donors in Scotland during 2019. Results: All samples collected on 17 March 2020 (n=500) were negative in the pseudotyped SARS-CoV-2 virus microneutralisation assay. Neutralising antibodies were detected in six of 500 donors from 23 to 26 March. The number of samples containing neutralising antibodies did not significantly rise after 5-6 April until the end of the study on 18 May. We found that infections were concentrated in certain postcodes, indicating that outbreaks of infection were extremely localised. In contrast, other areas remained comparatively untouched by the epidemic. Conclusion: Although blood donors are not representative of the overall population, we demonstrated that serosurveys of blood banks can serve as a useful tool for tracking the emergence and progression of an epidemic such as the SARS-CoV-2 outbreak.",
author = "{ISARIC4C Investigators} and C.P. Thompson and N.E. Grayson and R.S. Paton and J.S. Bolton and J. Louren{\c c}o and B.S. Penman and L.N. Lee and V. Odon and J. Mongkolsapaya and S. Chinnakannan and W. Dejnirattisai and M. Edmans and A. Fyfe and C. Imlach and K. Kooblall and N. Lim and C. Liu and C. L{\'o}pez-Camacho and C. McInally and A.L. McNaughton and N. Ramamurthy and J. Ratcliff and P. Supasa and O. Sampson and B. Wang and A.J. Mentzer and M. Turner and M.G. Semple and J.K. Baillie and H. Harvala and G.R. Screaton and N. Temperton and P. Klenerman and L.M. Jarvis and S. Gupta and P. Simmonds and J.K. Baillie and P.J.M. Openshaw and G. Carson and B. Alex and B. Bach and W.S. Barclay and D. Bogaert and M. Chand and G.S. Cooke and A.B. Docherty and J. Dunning and {da Silva Filipe}, A. and T. Fletcher and C.A. Green and E.M. Harrison and J.A. Hiscox and A.Y.W. Ho and P.W. Horby and S. Ijaz and S. Khoo and A. Law and W.S. Lim and L. Merson and A.M. Meynert and M. Noursadeghi and S.C. Moore and M. Palmarini and W.A. Paxton and G. Pollakis and N. Price and A. Rambaut and D.L. Robertson and C.D. Russell and V. Sancho-Shimizu and J.T. Scott and {de Silva}, T. and L. Sigfrid and T. Solomon and S. Sriskandan and D. Stuart and C. Summers and R.S. Tedder and E.C. Thomson and {Roger Thompson}, A.A. and R.S. Thwaites and L.C.W. Turtle and M. Zambon and H. Hardwick and C. Donohue and R. Lyons and F. Griffiths and W. Oosthuyzen and L. Norman and R. Pius and T.M. Drake and C.J. Fairfield and S. Knight and K.A. McLean and D. Murphy and C.A. Shaw and J. Dalton and J. Lee and D. Plotkin and M. Girvan and E. Saviciute and S. Roberts and J. Harrison and L. Marsh and M. Connor and S. Halpin and C. Jackson and C. Gamble and G. Leeming and M. Wham and S. Clohisey and R. Hendry and J. Scott-Brown and W. Greenhalf and V. Shaw and S. McDonald and S. Keating and K.A. Ahmed and J.A. Armstrong and M. Ashworth and I.G. Asiimwe and S. Bakshi and S.L. Barlow and L. Booth and B. Brennan and K. Bullock and B.W.A. Catterall and J.J. Clark and E.A. Clarke and S. Cole and L. Cooper and H. Cox and C. Davis and O. Dincarslan and C. Dunn and P. Dyer and A. Elliott and A. Evans and L. Finch and L.W.S. Fisher and T. Foster and I. Garcia-Dorival and P. Gunning and C. Hartley and A. Ho and R.L. Jensen and C.B. Jones and T.R. Jones and S. Khandaker and K. King and R.T. Kiy and C. Koukorava and A. Lake and S. Lant and D. Latawiec and L. Lavelle-Langham and D. Lefteri and L. Lett and L.A. Livoti and M. Mancini and L. McEvoy and J. McLauchlan and S. Metelmann and N.S. Miah and J. Middleton and J. Mitchell and E.G. Murphy and R. Penrice-Randal and J. Pilgrim and T. Prince and W. Reynolds and P.M. Ridley and D. Sales and V.E. Shaw and R.K. Shears and B. Small and K.S. Subramaniam and A. Szemiel and A. Taggart and J. Tanianis-Hughes and J. Thomas and E. Trochu and {van Tonder}, L. and E. Wilcock and J.E. Zhang and K. Adeniji and D. Agranoff and K. Agwuh and D. Ail and A. Alegria and B. Angus and A. Ashish and D. Atkinson and S. Bari and G. Barlow and S. Barnass and N. Barrett and C. Bassford and D. Baxter and M. Beadsworth and J. Bernatoniene and J. Berridge and N. Best and P. Bothma and D. Brealey and R. Brittain-Long and N. Bulteel and T. Burden and A. Burtenshaw and V. Caruth and D. Chadwick and D. Chambler and N. Chee and J. Child and S. Chukkambotla and T. Clark and P. Collini and C. Cosgrove and J. Cupitt and M.-T. Cutino-Moguel and P. Dark and C. Dawson and S. Dervisevic and P. Donnison and S. Douthwaite and I. DuRand and A. Dushianthan and T. Dyer and C. Evans and C. Eziefula and C. Fegan and A. Finn and D. Fullerton and S. Garg and A. Garg and E. Gkrania-Klotsas and J. Godden and A. Goldsmith and C. Graham and E. Hardy and S. Hartshorn and D. Harvey and P. Havalda and D.B. Hawcutt and M. Hobrok and L. Hodgson and A. Hormis and M. Jacobs and S. Jain and P. Jennings and A. Kaliappan and V. Kasipandian and S. Kegg and M. Kelsey and J. Kendall and C. Kerrison and I. Kerslake and O. Koch and G. Koduri and G. Koshy and S. Laha and S. Laird and S. Larkin and T. Leiner and P. Lillie and J. Limb and V. Linnett and J. Little and M. MacMahon and E. MacNaughton and R. Mankregod and H. Masson and E. Matovu and K. McCullough and R. McEwen and M. Meda and G. Mills and J. Minton and M. Mirfenderesky and K. Mohandas and Q. Mok and J. Moon and E. Moore and P. Morgan and C. Morris and K. Mortimore and S. Moses and M. Mpenge and R. Mulla and M. Murphy and M. Nagel and T. Nagarajan and M. Nelson and I. Otahal and M. Pais and S. Panchatsharam and H. Paraiso and B. Patel and N. Pattison and J. Pepperell and M. Peters and M. Phull and S. Pintus and J.S. Pooni and F. Post and D. Price and R. Prout and N. Rae and H. Reschreiter and T. Reynolds and N. Richardson and M. Roberts and D. Roberts and A. Rose and G. Rousseau and B. Ryan and T. Saluja and A. Shah and P. Shanmuga and A. Sharma and A. Shawcross and J. Sizer and M. Shankar-Hari and R. Smith and C. Snelson and N. Spittle and N. Staines and T. Stambach and R. Stewart and P. Subudhi and T. Szakmany and K. Tatham and C. Thompson and R. Thompson and A. Tridente and D. Tupper-Carey and M. Twagira and A. Ustianowski and N. Vallotton and L. Vincent-Smith and S. Visuvanathan and A. Vuylsteke and S. Waddy and R. Wake and A. Walden and I. Welters and T. Whitehouse and P. Whittaker and A. Whittington and M. Wijesinghe and M. Williams and L. Wilson and S. Wilson and S. Winchester and M. Wiselka and A. Wolverson and D.G. Wooton and A. Workman and B. Yates and P. Young and ISARIC4C Investigators",
note = "Cited By :15 Export Date: 31 August 2021",
year = "2020",
month = oct,
day = "22",
doi = "10.2807/1560-7917.ES.2020.25.42.2000685",
language = "English",
volume = "25",
journal = "Eurosurveillance",
issn = "1560-7917",
publisher = "EUR CENTRE DIS PREVENTION & CONTROL",
number = "42",
}