Determinants of dengue virus dispersal in the Americas

Orchid M Allicock, Nikita Sahadeo, Philippe Lemey, Albert J Auguste, Marc A. Suchard, Andrew Rambaut, Christine V F Carrington

Research output: Contribution to journalArticlepeer-review

Abstract

Dengue viruses (DENVs) are classified into four serotypes, each of which contains multiple genotypes. DENV genotypes introduced into the Americas over the past five decades have exhibited different rates and patterns of spatial dispersal. In order to understand factors underlying these patterns, we utilized a statistical framework that allows for the integration of ecological, socioeconomic, and air transport mobility data as predictors of viral diffusion while inferring the phylogeographic history. Predictors describing spatial diffusion based on several covariates were compared using a generalized linear model approach, where the support for each scenario and its contribution is estimated simultaneously from the data set. Although different predictors were identified for different serotypes, our analysis suggests that overall diffusion of DENV-1, -2, and -3 in the Americas was associated with airline traffic. The other significant predictors included human population size, the geographical distance between countries and between urban centers and the density of people living in urban environments.
Original languageEnglish
Article numberveaa074
Number of pages13
JournalVirus Evolution
Volume6
Issue number2
Early online date1 Jul 2020
DOIs
Publication statusPublished - 2 Dec 2020

Keywords

  • dengue virus
  • Bayesian phylogeography
  • hypothesis testing
  • spatial diffustion

Fingerprint Dive into the research topics of 'Determinants of dengue virus dispersal in the Americas'. Together they form a unique fingerprint.

Cite this