@article{eab30fa1d07646618ad45ad91bbb67fb,
title = "Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes",
author = "Yipeng Cheng and Danni Gadd and Christian Gieger and Karla Monterrubio-Gomez and Yufei Zhang and Imrich Berta and Michael Stam and Natalia Szlachetka and Evgenii Lobzaev and Nicola Wrobel and Lee Murphy and Archie Campbell and Cliff Nangle and Rosie Walker and Chloe Fawns-Ritchie and Annette Peters and Wolfgang Rathmann and Porteous, {David John} and Evans, {Kathryn Louise} and McIntosh, {Andrew M} and Cannings, {Timothy I} and Melanie Waldenberger and Andrea Ganna and McCartney, {Daniel L} and Vallejos, {Catalina A} and Marioni, {Riccardo E}",
note = "Funding Information: This research was funded in whole, or in part, by the Wellcome Trust (nos. 104036/Z/14/Z, 108890/Z/15/Z and 216767/Z/19/Z). For the purpose of open access, we have applied a CC BY public copyright licence to any author accepted manuscript version arising from this submission. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (no. CZD/16/6) and the Scottish Funding Council (no. HR03006) and is currently supported by the Wellcome Trust (no. 216767/Z/19/Z). DNAm profiling of the Generation Scotland samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award {\textquoteleft}STratifying Resilience and Depression Longitudinally{\textquoteright} (ref. no. 104036/Z/14/Z)). The DNAm data assayed for Generation Scotland was partially funded by a 2018 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (ref. no. 27404; awardee: D. M. Howard) and by a JMAS SIM fellowship from the Royal College of Physicians of Edinburgh (awardee: H. C. Whalley). Y.C. is supported by the University of Edinburgh and University of Helsinki joint PhD program in Human Genomics. D.A.G. is supported by funding from the Wellcome Trust 4-year PhD in Translational Neuroscience—training the next generation of basic neuroscientists to embrace clinical research (no. 108890/Z/15/Z). C.A.V. is a Chancellor{\textquoteright}s Fellow funded by the University of Edinburgh. D.L.M. and R.E.M. are supported by an Alzheimer{\textquoteright}s Research UK major project grant no. ARUK-PG2017B-10. R.E.M. is supported by an Alzheimer{\textquoteright}s Society major project grant no. AS-PG-19b-010. M.J.S., N.S. and E.L. are supported by the United Kingdom Research and Innovation (grant EP/S02431X/1), UKRI Centre for Doctoral Training in Biomedical AI at the University of Edinburgh, School of Informatics. Recruitment to the CovidLife study was facilitated by the Scottish Health Research Register (SHARE) and Biobank. SHARE is supported by NHS Research Scotland, the universities of Scotland and the Chief Scientist Office of the Scottish Government. The KORA S4 study was initiated and financed by the Helmholtz Zentrum M{\"u}nchen—German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. Furthermore, the KORA research has been supported by the Munich Center of Health Sciences, Ludwig-Maximilians-Universit{\"a}t M{\"u}nchen as part of LMUinnovativ and is supported by the German Centre for Cardiovascular Research. The KORA S4 study is funded by the Bavarian State Ministry of Health and Care through the research project DigiMed Bayern ( www.digimed-bayern.de ). Funding Information: R.E.M. has received a speaker fee from Illumina and is an advisor to the Epigenetic Clock Development Foundation. A.M.M. has previously received speaker fees from Janssen and Illumina and research funding from The Sackler Trust. L.M. has received payment from Illumina for presentations and consultancy. The other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
month = apr,
day = "6",
doi = "10.1038/s43587-023-00391-4",
language = "English",
journal = "Nature Aging",
issn = "2662-8465",
publisher = "Springer Nature Switzerland AG",
}