Abstract
An antiserum raised in guineapigs showed positive immunoelectrophoretic reaction with sera from 16 of 17 patients with cystic fibrosis, 8 of 9 obligate heterozygotes, and only 1 of 15 normal subjects. The antiserum appeared to be specific to the cystic-fibrosis protein described by Wilson and colleagues. Precipitin peaks were larger with sera from cystic-fibrosis homozygotes than from heterozygotes, suggesting the possibility of a new quantitative biochemical assay for cystic fibrosis.
| Original language | English |
|---|---|
| Pages (from-to) | 330-1 |
| Number of pages | 2 |
| Journal | The Lancet |
| Volume | 1 |
| Issue number | 8164 |
| DOIs | |
| Publication status | Published - 16 Feb 1980 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Antibody Specificity
- Cystic Fibrosis
- Genes
- Guinea Pigs
- Heterozygote
- Heterozygote Detection
- Homozygote
- Humans
- Immune Sera
- Immunoelectrophoresis
- Immunoglobulin G
- Isoelectric Focusing
- Mutation
- Proteins
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