Development of a SNP linkage map and genome-wide association study for resistance to Aeromonas hydrophila in pacu (Piaractus mesopotamicus)

Vito Antonio Mastrochirico Filho, Carolina H. S. Borges, Milena V. Freitas, Raquel Belini Ariede , Fabiana Pilarski, Ricardo Utsunomia, Roberto Carvalheiro, Alejandro Gutierrez, Carolina Penaloza, Jose M. Yanez, Ross Houston, Diogo Teruo Hashimoto

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Pacu (Piaractus mesopotamicus) is one of the most important Neotropical aquaculture species from South America. Disease outbreaks caused by Aeromonas hydrophila infection have been considered significant contributors to the declining levels of pacu production. The current implementation of genomic selection for disease resistance has been adopted as a powerful strategy for improvement in fish species. This study aimed to investigate the genetic architecture of resistance to A. hydrophila in pacu via Genome-Wide Association Study (GWAS), the identification of suggestive Quantitative Trait Loci (QTLs) and putative genes associated with this trait. The genetic data were obtained from 381 juvenile individuals belonging to 14 full-sibling families. An experimental challenge was performed to gain access to the levels of genetic variation for resistance against the bacteria using the following trait definitions: binary test survival (TS) and time of death (TD).
Original languageEnglish
JournalBMC Genomics
Early online date29 Sept 2020
DOIs
Publication statusE-pub ahead of print - 29 Sept 2020

Keywords / Materials (for Non-textual outputs)

  • Motile Aeromonas septicemia
  • Disease outbreaks
  • Resistance QTLs
  • Fish farming

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