TY - JOUR
T1 - Development of animal recombinant dna vaccine and its efficacy in foxes
AU - Kieny, Marie Paule
AU - Blancou, Jean
AU - Lathe, Richard
AU - Pastoret, Pierre Paul
AU - Soulebot, Jean Paul
AU - Desmettre, Philippe
AU - Lecocq, Jean Pierre
PY - 1988
Y1 - 1988
N2 - Rabies is prevalent in most parts of the world. An extensive reservoir of the disease is present in the population of wild animals. The fox in particular is a major vector of the disease in North America and Europe. Although attempts to control rabies by vaccination of wild carnivores with attenuated rabies virus have met with some success, this approach remains controversial. The potential of a recombinant vaccinia virus expressing the rabies glycoprotein for the protection of foxes against rabies was examined. Both the parental (wild-type) and recombinant viruses were found to be innocuous to foxes. Inoculation of live recombinant virus via the subcutaneous, intradermal, or oral routes uniformly elicited high titers of neutralizing antibodies, and animals that received 106plaque-forming units of the recombinant virus in bait resisted severe challenge with live rabies virus.
AB - Rabies is prevalent in most parts of the world. An extensive reservoir of the disease is present in the population of wild animals. The fox in particular is a major vector of the disease in North America and Europe. Although attempts to control rabies by vaccination of wild carnivores with attenuated rabies virus have met with some success, this approach remains controversial. The potential of a recombinant vaccinia virus expressing the rabies glycoprotein for the protection of foxes against rabies was examined. Both the parental (wild-type) and recombinant viruses were found to be innocuous to foxes. Inoculation of live recombinant virus via the subcutaneous, intradermal, or oral routes uniformly elicited high titers of neutralizing antibodies, and animals that received 106plaque-forming units of the recombinant virus in bait resisted severe challenge with live rabies virus.
UR - http://www.scopus.com/inward/record.url?scp=0024114913&partnerID=8YFLogxK
U2 - 10.1093/clinids/10.Supplement_4.S799
DO - 10.1093/clinids/10.Supplement_4.S799
M3 - Article
C2 - 3206090
AN - SCOPUS:0024114913
SN - 0162-0886
VL - 10
SP - S799-S802
JO - Reviews of Infectious Diseases
JF - Reviews of Infectious Diseases
ER -