Development of multiplexed nucleic acid testing for human immunodeficiency virus type 1 and hepatitis C virus

A Cleland, C Davis, N Adams, C Lycett, L M Jarvis, H Holmes, P Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract

In most Western countries, blood donations are routinely screened for hepatitis C virus (HCV) RNA by polymerase chain reaction (PCR) or other nucleic acid tests. We describe the development of a multiplexed assay for human immunodeficiency virus type 1 (HIV-1) and HCV in an internally controlled PCR suitable for large-scale blood donor screening.
Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalVox Sanguinis
Volume81
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Conserved Sequence
  • DNA Primers
  • Feasibility Studies
  • HIV Long Terminal Repeat
  • HIV-1
  • Hepacivirus
  • Humans
  • Polymerase Chain Reaction
  • RNA, Viral
  • Sensitivity and Specificity
  • Sequence Alignment

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