Projects per year
Pyrazolopyrimidines with potent antiproliferative properties were developed by an adaptive strategy that applies ligand-based design and phenotypic screening iteratively, and is informed by biochemi-cal assays. To drive development towards specific onco-pathways, compounds were tested against cancer cells that overexpress, or not, AXL kinase. Identified phenotypic hits were found to inhibit oncotargets AXL, RET and FLT3. Subsequent optimization generated antiproliferative lead compounds with unique selectivity profiles, including selective AXL inhibitors and a highly-potent inhibitor of FLT3.
FingerprintDive into the research topics of 'Development of potent inhibitors of receptor tyrosine kinases by ligand-based drug design and target-biased phenotypic screening'. Together they form a unique fingerprint.
- 1 Finished
Invasion and metastasis; understanding and targeting an adhesion protein network - Programme Grant Renewal
1/05/13 → 31/08/18
- Deanery of Molecular, Genetic and Population Health Sciences - Personal Chair of Medicinal Chemistry
Person: Academic: Research Active