Developmental trajectories of ADHD symptoms in a large population-representative longitudinal study

Aja Louise Murray, Hildigunnur Anna Hall, Lydia Speyer, Lara Carter, Dan Mirman, Arthur Caye, Luis Rohde

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background: Previous research has suggested that there is substantial heterogeneity in the developmental trajectories of ADHD symptoms. Sometimes qualitative distinctions between trajectories with different ages of onset and/or patterns of remission are made; however, little is known about the predictors and broader clinical meaningfulness of these candidate ‘developmental subtypes’ of ADHD symptoms. 
Methods: We applied latent class growth analysis to data from the UK Millennium Cohort Study (MCS; N=11,316; ages 3,5,7,11 and 14) to evaluate whether developmental trajectories of ADHD symptoms differing in early life predictors could be identified. Our optimal model included six trajectory groups, labelled unaffected (34.9% of the sample), mildly affected (24.1%), subclinical remitting (12.8%), pre-school onset partially remitting (14.1%), developmentally increasing (7.6%), and pre-school onset persistent (6.4%). 
Results: Factors such as gender, conduct problems, cognitive ability, maternal education, premature birth, peer problems, and school readiness scores differentiated between specific ADHD symptom trajectories. 
Conclusions: Taken together, our findings provide preliminary evidence that distinguishing different trajectories of ADHD symptoms could be clinically informative.
Original languageEnglish
Number of pages7
JournalPsychological Medicine
Early online date26 Mar 2021
Publication statusE-pub ahead of print - 26 Mar 2021

Keywords / Materials (for Non-textual outputs)

  • attention-deficit/hyperactivity disorder
  • developmental trajectories
  • onset
  • remission
  • persistence
  • latent class growth analysis


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