Developments in transgenic technology: applications for medicine

Cheryl V Hunter; Laurence S Tiley; Helen M Sang

doi:10.1016/j.molmed.2005.04.001

Developments in transgenic technology: applications for medicine

Cheryl V Hunter, Laurence S Tiley, Helen M Sang

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Recent advances in the efficiency of transgenic technology have important implications for medicine. The production of therapeutic proteins from animal bioreactors is well established and the first products are close to market. The genetic modification of pigs to improve their suitability as organ donors for xenotransplantation has been initiated, but many challenges remain. The use of transgenesis, in combination with the method of RNA interference to knock down gene expression, has been proposed as a method for making animals resistant to viral diseases, which could reduce the likelihood of transmission to humans. Here, the latest developments in transgenic technology and their applications relevant to medicine and human health will be discussed.

Original language	English
Pages (from-to)	293-8
Number of pages	6
Journal	Trends in Molecular Medicine
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/j.molmed.2005.04.001
Publication status	Published - Jun 2005

Keywords / Materials (for Non-textual outputs)

Animals
Bioreactors
Biotechnology
Cell Nucleus
Cytoplasm
Disease Models, Animal
Genetic Engineering
Humans
RNA Interference
RNA, Messenger
Transgenes
Transplantation
Transplantation, Heterologous

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10.1016/j.molmed.2005.04.001

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title = "Developments in transgenic technology: applications for medicine",

abstract = "Recent advances in the efficiency of transgenic technology have important implications for medicine. The production of therapeutic proteins from animal bioreactors is well established and the first products are close to market. The genetic modification of pigs to improve their suitability as organ donors for xenotransplantation has been initiated, but many challenges remain. The use of transgenesis, in combination with the method of RNA interference to knock down gene expression, has been proposed as a method for making animals resistant to viral diseases, which could reduce the likelihood of transmission to humans. Here, the latest developments in transgenic technology and their applications relevant to medicine and human health will be discussed.",

keywords = "Animals, Bioreactors, Biotechnology, Cell Nucleus, Cytoplasm, Disease Models, Animal, Genetic Engineering, Humans, RNA Interference, RNA, Messenger, Transgenes, Transplantation, Transplantation, Heterologous",

author = "Hunter, {Cheryl V} and Tiley, {Laurence S} and Sang, {Helen M}",

year = "2005",

month = jun,

doi = "10.1016/j.molmed.2005.04.001",

language = "English",

volume = "11",

pages = "293--8",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Developments in transgenic technology

T2 - applications for medicine

AU - Hunter, Cheryl V

AU - Tiley, Laurence S

AU - Sang, Helen M

PY - 2005/6

Y1 - 2005/6

N2 - Recent advances in the efficiency of transgenic technology have important implications for medicine. The production of therapeutic proteins from animal bioreactors is well established and the first products are close to market. The genetic modification of pigs to improve their suitability as organ donors for xenotransplantation has been initiated, but many challenges remain. The use of transgenesis, in combination with the method of RNA interference to knock down gene expression, has been proposed as a method for making animals resistant to viral diseases, which could reduce the likelihood of transmission to humans. Here, the latest developments in transgenic technology and their applications relevant to medicine and human health will be discussed.

AB - Recent advances in the efficiency of transgenic technology have important implications for medicine. The production of therapeutic proteins from animal bioreactors is well established and the first products are close to market. The genetic modification of pigs to improve their suitability as organ donors for xenotransplantation has been initiated, but many challenges remain. The use of transgenesis, in combination with the method of RNA interference to knock down gene expression, has been proposed as a method for making animals resistant to viral diseases, which could reduce the likelihood of transmission to humans. Here, the latest developments in transgenic technology and their applications relevant to medicine and human health will be discussed.

KW - Animals

KW - Bioreactors

KW - Biotechnology

KW - Cell Nucleus

KW - Cytoplasm

KW - Disease Models, Animal

KW - Genetic Engineering

KW - Humans

KW - RNA Interference

KW - RNA, Messenger

KW - Transgenes

KW - Transplantation

KW - Transplantation, Heterologous

U2 - 10.1016/j.molmed.2005.04.001

DO - 10.1016/j.molmed.2005.04.001

M3 - Article

C2 - 15949771

SN - 1471-4914

VL - 11

SP - 293

EP - 298

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 6

ER -

Developments in transgenic technology: applications for medicine

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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