Diabetes mellitus induces bone marrow microangiopathy

Atsuhiko Oikawa; Mauro Siragusa; Federico Quaini; Giuseppe Mangialardi; Rajesh G Katare; Andrea Caporali; Jaap D van Buul; Floris P J van Alphen; Gallia Graiani; Gaia Spinetti; Nicolle Kraenkel; Lucia Prezioso; Costanza Emanueli; Paolo Madeddu

doi:10.1161/ATVBAHA.109.200154

Diabetes mellitus induces bone marrow microangiopathy

Atsuhiko Oikawa, Mauro Siragusa, Federico Quaini, Giuseppe Mangialardi, Rajesh G Katare, Andrea Caporali, Jaap D van Buul, Floris P J van Alphen, Gallia Graiani, Gaia Spinetti, Nicolle Kraenkel, Lucia Prezioso, Costanza Emanueli, Paolo Madeddu

Research output: Contribution to journal › Article › peer-review

Abstract

The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular remodeling with negative consequence for BM homeostasis.

Original language	English
Pages (from-to)	498-508
Number of pages	11
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1161/ATVBAHA.109.200154
Publication status	Published - Mar 2010

Keywords

Animals
Antigens, Ly
Bone Marrow
Cells, Cultured
Diabetes Mellitus, Experimental
Diabetic Angiopathies
Disease Models, Animal
Endothelium, Vascular
Homeostasis
Male
Membrane Proteins
Mice
Mice, Inbred Strains
Oxidative Stress
Proto-Oncogene Proteins c-kit
Regional Blood Flow
Streptozocin

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10.1161/ATVBAHA.109.200154

Diabetes mellitus induces bone marrow microangiopathy
Copyright © 2010 by American Heart Association, Inc. All rights reserved
Accepted author manuscript, 7.21 MB

http://atvb.ahajournals.org/content/30/3/498

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Oikawa, A., Siragusa, M., Quaini, F., Mangialardi, G., Katare, R. G., Caporali, A., van Buul, J. D., van Alphen, F. P. J., Graiani, G., Spinetti, G., Kraenkel, N., Prezioso, L., Emanueli, C., & Madeddu, P. (2010). Diabetes mellitus induces bone marrow microangiopathy. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(3), 498-508. https://doi.org/10.1161/ATVBAHA.109.200154

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title = "Diabetes mellitus induces bone marrow microangiopathy",

abstract = "The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular remodeling with negative consequence for BM homeostasis.",

keywords = "Animals, Antigens, Ly, Bone Marrow, Cells, Cultured, Diabetes Mellitus, Experimental, Diabetic Angiopathies, Disease Models, Animal, Endothelium, Vascular, Homeostasis, Male, Membrane Proteins, Mice, Mice, Inbred Strains, Oxidative Stress, Proto-Oncogene Proteins c-kit, Regional Blood Flow, Streptozocin",

author = "Atsuhiko Oikawa and Mauro Siragusa and Federico Quaini and Giuseppe Mangialardi and Katare, {Rajesh G} and Andrea Caporali and {van Buul}, {Jaap D} and {van Alphen}, {Floris P J} and Gallia Graiani and Gaia Spinetti and Nicolle Kraenkel and Lucia Prezioso and Costanza Emanueli and Paolo Madeddu",

year = "2010",

month = mar,

doi = "10.1161/ATVBAHA.109.200154",

language = "English",

volume = "30",

pages = "498--508",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

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AU - Oikawa, Atsuhiko

AU - Siragusa, Mauro

AU - Quaini, Federico

AU - Mangialardi, Giuseppe

AU - Katare, Rajesh G

AU - Caporali, Andrea

AU - van Buul, Jaap D

AU - van Alphen, Floris P J

AU - Graiani, Gallia

AU - Spinetti, Gaia

AU - Kraenkel, Nicolle

AU - Prezioso, Lucia

AU - Emanueli, Costanza

AU - Madeddu, Paolo

PY - 2010/3

Y1 - 2010/3

N2 - The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular remodeling with negative consequence for BM homeostasis.

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KW - Animals

KW - Antigens, Ly

KW - Bone Marrow

KW - Cells, Cultured

KW - Diabetes Mellitus, Experimental

KW - Diabetic Angiopathies

KW - Disease Models, Animal

KW - Endothelium, Vascular

KW - Homeostasis

KW - Male

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred Strains

KW - Oxidative Stress

KW - Proto-Oncogene Proteins c-kit

KW - Regional Blood Flow

KW - Streptozocin

U2 - 10.1161/ATVBAHA.109.200154

DO - 10.1161/ATVBAHA.109.200154

M3 - Article

C2 - 20042708

VL - 30

SP - 498

EP - 508

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 3

ER -

Diabetes mellitus induces bone marrow microangiopathy

Abstract

Keywords

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