Diabetes mellitus induces bone marrow microangiopathy

Atsuhiko Oikawa, Mauro Siragusa, Federico Quaini, Giuseppe Mangialardi, Rajesh G Katare, Andrea Caporali, Jaap D van Buul, Floris P J van Alphen, Gallia Graiani, Gaia Spinetti, Nicolle Kraenkel, Lucia Prezioso, Costanza Emanueli, Paolo Madeddu

Research output: Contribution to journalArticlepeer-review


The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular remodeling with negative consequence for BM homeostasis.
Original languageEnglish
Pages (from-to)498-508
Number of pages11
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number3
Publication statusPublished - Mar 2010


  • Animals
  • Antigens, Ly
  • Bone Marrow
  • Cells, Cultured
  • Diabetes Mellitus, Experimental
  • Diabetic Angiopathies
  • Disease Models, Animal
  • Endothelium, Vascular
  • Homeostasis
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Inbred Strains
  • Oxidative Stress
  • Proto-Oncogene Proteins c-kit
  • Regional Blood Flow
  • Streptozocin


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