Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD

David A McAllister, John D Maclay, Nicholas L Mills, Andrew Leitch, Philip Reid, Ross Carruthers, Jennifer O'Connor, Lawrence McAlpine, George Chalmers, David E Newby, Elaine Clark, Peter W Macfarlane, William Macnee

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Cardiovascular disease is common in chronic obstructive pulmonary disease (COPD) and raised troponin is common in exacerbations. However, the prevalence of myocardial infarction following hospitalisation for exacerbation of COPD is unknown. Patients aged ≥ 40 yrs hospitalised with acute exacerbation of COPD (n = 242) with ≥ 10 pack-yrs of cigarette smoking were included in a prospective case series conducted in four hospitals. Patients whose primary presenting complaint was chest pain or who had an alternative diagnosis were excluded. Chest pain histories, serial ECGs and troponin levels were obtained. The mean ± SD age was 69 ± 9 yrs; 108 (45%) patients were male and almost half were current smokers. 124 (51%; 95% CI 48-58%) patients had chest pain, which was exertional in 62 (26%). 24 (10%) had raised troponin, among whom, 20 (8.3%; 95% CI 5.1-12.5%) had chest pain and/or serial ECG changes, fulfilling the 2007 Universal Definition of Myocardial Infarction. Neither chest pain (p = 0.77) nor serial ECG changes (p = 0.39) were associated with raised troponin. Raised troponin, chest pain and serial ECG changes are common in patients admitted to hospital with exacerbation of COPD. Overall, one in 12 patients met the criteria for myocardial infarction. Whether these patients would benefit from further cardiac investigation is unknown.
Original languageEnglish
Pages (from-to)1097-1103
Number of pages7
JournalEuropean Respiratory Journal
Issue number5
Publication statusPublished - 1 May 2012


Dive into the research topics of 'Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD'. Together they form a unique fingerprint.

Cite this