Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review

Anastasios Koulaouzidis*, Emanuele Rondonotti, Andry Giannakou, John N. Plevris

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Background: Iron-deficiency anemia (IDA) is the most common cause of anemia worldwide. Current guidelines recommend the use of small-bowel capsule endoscopy (SBCE) in IDA. Evidence of the validity of SBCE in patients with IDA alone is still limited.

Objective: To assess the diagnostic yield (DY) of SBCE in IDA by pooling data from relevant studies.

Design: Systematic review and meta-analysis. Fixed-effects or random-effects models were used as appropriate.

Setting: Studies that estimated the ID-Y of SCBE in IDA were identified. Two investigators independently conducted the search and data extraction.

Patients: A total of 24 studies enrolling 1960 patients with IDA who underwent SBCE were included.

Main Outcome Measurements: Per-patient DY, with 95% confidence intervals. Subgroup analysis was also performed.

Results: The pooled DY of SBCE in IDA, evaluated by a random-effects model, was 47% (95% CI, 42%-52%), but there was statistically significant heterogeneity among the included studies (inconsistency index [I-2] = 78.8%, P

Limitations: Heterogeneity of studies, retrospective design, and selection bias.

Conclusions: This analysis demonstrates the validity of SBCE in the investigation of patients with IDA and negative findings on a previous diagnostic workup, although certain factors such as heterogeneity and quality of the included studies should be taken into account. (Gastrointest Endosc 20:12;76:983-92.)

Original languageEnglish
Pages (from-to)983-992
Number of pages10
JournalGastrointestinal Endoscopy
Volume76
Issue number5
DOIs
Publication statusPublished - Nov 2012

Keywords / Materials (for Non-textual outputs)

  • SINGLE-CENTER EXPERIENCE
  • CONSECUTIVE PATIENTS
  • GASTROINTESTINAL MALIGNANCY
  • VIDEOCAPSULE ENDOSCOPY
  • CLINICAL-PRACTICE
  • METAANALYSIS
  • ENTEROSCOPY
  • DISEASE
  • ROUTINE
  • LESIONS

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