Abstract / Description of output
Background: Iron-deficiency anemia (IDA) is the most common cause of anemia worldwide. Current guidelines recommend the use of small-bowel capsule endoscopy (SBCE) in IDA. Evidence of the validity of SBCE in patients with IDA alone is still limited.
Objective: To assess the diagnostic yield (DY) of SBCE in IDA by pooling data from relevant studies.
Design: Systematic review and meta-analysis. Fixed-effects or random-effects models were used as appropriate.
Setting: Studies that estimated the ID-Y of SCBE in IDA were identified. Two investigators independently conducted the search and data extraction.
Patients: A total of 24 studies enrolling 1960 patients with IDA who underwent SBCE were included.
Main Outcome Measurements: Per-patient DY, with 95% confidence intervals. Subgroup analysis was also performed.
Results: The pooled DY of SBCE in IDA, evaluated by a random-effects model, was 47% (95% CI, 42%-52%), but there was statistically significant heterogeneity among the included studies (inconsistency index [I-2] = 78.8%, P
Limitations: Heterogeneity of studies, retrospective design, and selection bias.
Conclusions: This analysis demonstrates the validity of SBCE in the investigation of patients with IDA and negative findings on a previous diagnostic workup, although certain factors such as heterogeneity and quality of the included studies should be taken into account. (Gastrointest Endosc 20:12;76:983-92.)
Original language | English |
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Pages (from-to) | 983-992 |
Number of pages | 10 |
Journal | Gastrointestinal Endoscopy |
Volume | 76 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 2012 |
Keywords / Materials (for Non-textual outputs)
- SINGLE-CENTER EXPERIENCE
- CONSECUTIVE PATIENTS
- GASTROINTESTINAL MALIGNANCY
- VIDEOCAPSULE ENDOSCOPY
- CLINICAL-PRACTICE
- METAANALYSIS
- ENTEROSCOPY
- DISEASE
- ROUTINE
- LESIONS