Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to N-Boc Imines and Nitroalkenes

Daniel Best, Szymon Kujawa, Hon Wai Lam

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A chiral Pd(II)–bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.
Original languageEnglish
Pages (from-to)18193–18196
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number44
DOIs
Publication statusPublished - 7 Nov 2012

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