Diastereoselective cobalt-catalyzed reductive aldol cyclizations using diethylzinc as the stoichiometric reductant

Hon Wai Lam, Pekka M. Joensuu, Gordon J. Murray, Euan A. F. Fordyce, Oscar Prieto, Thomas Luebbers

Research output: Contribution to journalArticlepeer-review

Abstract

Cobalt catalysis enables a new method for the generation of zinc enolates using diethylzinc to reduce alpha,ss-unsaturated amides. This method has been applied to a high-yielding diastereoselective reductive aldol cyclization.

Original languageEnglish
Pages (from-to)3729-3732
Number of pages4
JournalOrganic letters
Volume8
Issue number17
DOIs
Publication statusPublished - 17 Aug 2006

Keywords

  • REFORMATSKY-TYPE REACTION
  • ALPHA,BETA-UNSATURATED CARBOXAMIDES
  • ENANTIOSELECTIVE SYNTHESIS
  • KETONES
  • ALKYNES
  • ALPHA
  • CYCLOREDUCTIONS
  • HOMOALLYLATION
  • 1,4-REDUCTION
  • HYDROGENATION

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