Diastolic function is strongly and independently associated with cardiorespiratory fitness in central obesity

M. Turzyniecka, S. H. Wild, A. J. Krentz, A. J. Chipperfield, G. F. Clough, C. D. Byrne

Research output: Contribution to journalArticlepeer-review

Abstract

Turzyniecka M, Wild SH, Krentz AJ, Chipperfield AJ, Clough GF, Byrne CD. Diastolic function is strongly and independently associated with cardiorespiratory fitness in central obesity. J Appl Physiol 108: 1568-1574, 2010. First published March 25, 2010; doi:10.1152/japplphysiol.00023.2010.-Cardiorespiratory fitness [maximal O-2 consumption ((V) over dotO(2max))] is an independent risk factor for type 2 diabetes; but in individuals at risk, factors influencing (V) over dotO(2max) are poorly understood. We tested the hypothesis that (V) over dotO(2max) is associated with diastolic function [subendocardial variability ratio (SEVR), %], as diastolic function influences myocardial perfusion. We studied 47 men and women with central obesity without diabetes. We measured fitness ((V) over dotO(2max)) by treadmill testing and diastolic function (SEVR%) by pulse-wave analysis. We measured other factors influencing this relationship: insulin sensitivity [whole body glucose uptake-to-insulin concentration ratio (M/I)] by hyperinsulinemic euglycemic clamp, fatness by MR imaging and dual-energy X-ray absorptiometry, physical activity energy expenditure (metabolic equivalents of tasks) by the Sensewear Pro2 device, and muscle microvascular exchange capacity (capillary filtration coefficient) by venous plethysmography. Mean age of the subjects was 51 +/- 9 (SD) yr. (V) over dotO(2max) was associated with SEVR% (r = 0.50, P = 0.001), fatness (r = -0.39, P = 0.008), and HbA1c (r = -0.35, P = 0.018), but not with whole body glucose uptake-to-insulin concentration ratio, metabolic equivalents of tasks, or capillary filtration coefficient. In regression modeling with age, sex, fatness, and SEVR% as explanatory variables, only age, sex, and SEVR% were independently associated with (V) over dotO(2max) (SEVR% -standardized B coefficient = 0.37, 95% confidence interval = 0.003-0.18, P = 0.007). This model identified 46% of the variance in (V) over dotO(2max) (R-2 = 0.46, P = 0.0001). There was a strong, independent association between (V) over dotO(2max) and a measure of diastolic function in sedentary individuals with central obesity.

Original languageEnglish
Pages (from-to)1568-1574
Number of pages7
JournalJournal of Applied Physiology
Volume108
Issue number6
DOIs
Publication statusPublished - Jun 2010

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