Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains: common and specific effects from PAO1 and PA14 strains

Sergio Carilla-Latorre, Javier Calvo-Garrido, Gareth Bloomfield, Jason Skelton, Robert R Kay, Alasdair Ivens, José L Martinez, Ricardo Escalante

Research output: Contribution to journalArticlepeer-review

Abstract

Pseudomonas aeruginosa is one of the most relevant human opportunistic bacterial pathogens. Two strains (PAO1 and PA14) have been mainly used as models for studying virulence of P. aeruginosa. The strain PA14 is more virulent than PAO1 in a wide range of hosts including insects, nematodes and plants. Whereas some of the differences might be attributable to concerted action of determinants encoded in pathogenicity islands present in the genome of PA14, a global analysis of the differential host responses to these P. aeruginosa strains has not been addressed. Little is known about the host response to infection with P. aeruginosa and whether or not the global host transcription is being affected as a defense mechanism or altered in the benefit of the pathogen. Since the social amoeba Dictyostelium discoideum is a suitable host to study virulence of P. aeruginosa and other pathogens, we used available genomic tools in this model system to study the transcriptional host response to P. aeruginosa infection.
Original languageEnglish
Pages (from-to)109
Number of pages15
JournalBMC Microbiology
Volume8
DOIs
Publication statusPublished - 30 Jun 2008

Keywords

  • Virulence
  • Gene Expression Profiling
  • Animals
  • Protozoan Proteins
  • Humans
  • Disease Models, Animal
  • Gene Expression Regulation
  • Pseudomonas aeruginosa
  • Species Specificity
  • Genome, Protozoan
  • Dictyostelium

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