Dielectrophoresis: A Review of Applications for Stem Cell Research

Ronald Pethig, Anoop Menachery, Steve Pells, Paul De Sousa

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Dielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels. Demonstrated capabilities include the enrichment of haematopoetic stem cells from bone marrow and peripheral blood, and adult stem cells from adipose tissue. Recent research suggests that this technique can predict the ultimate fate of neural stem cells after differentiation before the appearance of specific cell-surface proteins. This review summarises the properties of cells that contribute to their dielectrophoretic behaviour, and their relevance to stem cell research and translational applications.

Original languageEnglish
Article number182581
Pages (from-to)-
Number of pages7
JournalJournal of Biomedicine and Biotechnology
DOIs
Publication statusPublished - 2010

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