Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends, Sheila A Rodwell

Research output: Contribution to journalArticlepeer-review

Abstract

BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers.
Original languageEnglish
Pages (from-to)99
JournalBMC Cancer
Volume10
DOIs
Publication statusPublished - 2010

Keywords / Materials (for Non-textual outputs)

  • Adenocarcinoma
  • Adenoma
  • Aged
  • Colorectal Neoplasms
  • Diet
  • England
  • Female
  • Genes, ras
  • Humans
  • Life Style
  • Male
  • Middle Aged
  • Mutation
  • Prospective Studies
  • Proto-Oncogene Proteins B-raf

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