Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Adam Naguib; Panagiota N Mitrou; Laura J Gay; James C Cooke; Robert N Luben; Richard Y Ball; Alison McTaggart; Mark J Arends; Sheila A Rodwell

doi:10.1186/1471-2407-10-99

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends, Sheila A Rodwell

School of Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers.

Original language	English
Pages (from-to)	99
Journal	BMC Cancer
Volume	10
DOIs	https://doi.org/10.1186/1471-2407-10-99
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Adenocarcinoma
Adenoma
Aged
Colorectal Neoplasms
Diet
England
Female
Genes, ras
Humans
Life Style
Male
Middle Aged
Mutation
Prospective Studies
Proto-Oncogene Proteins B-raf

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10.1186/1471-2407-10-99

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study
© 2010 Naguib et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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http://www.biomedcentral.com/1471-2407/10/99

Cite this

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title = "Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study",

abstract = "BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers.",

keywords = "Adenocarcinoma, Adenoma, Aged, Colorectal Neoplasms, Diet, England, Female, Genes, ras, Humans, Life Style, Male, Middle Aged, Mutation, Prospective Studies, Proto-Oncogene Proteins B-raf",

author = "Adam Naguib and Mitrou, \{Panagiota N\} and Gay, \{Laura J\} and Cooke, \{James C\} and Luben, \{Robert N\} and Ball, \{Richard Y\} and Alison McTaggart and Arends, \{Mark J\} and Rodwell, \{Sheila A\}",

year = "2010",

doi = "10.1186/1471-2407-10-99",

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T1 - Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

AU - Naguib, Adam

AU - Mitrou, Panagiota N

AU - Gay, Laura J

AU - Cooke, James C

AU - Luben, Robert N

AU - Ball, Richard Y

AU - McTaggart, Alison

AU - Arends, Mark J

AU - Rodwell, Sheila A

PY - 2010

Y1 - 2010

N2 - BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers.

AB - BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers.

KW - Adenocarcinoma

KW - Adenoma

KW - Aged

KW - Colorectal Neoplasms

KW - Diet

KW - England

KW - Female

KW - Genes, ras

KW - Humans

KW - Life Style

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prospective Studies

KW - Proto-Oncogene Proteins B-raf

U2 - 10.1186/1471-2407-10-99

DO - 10.1186/1471-2407-10-99

M3 - Article

C2 - 20233436

SN - 1471-2407

VL - 10

SP - 99

JO - BMC Cancer

JF - BMC Cancer

ER -

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Abstract

Keywords / Materials (for Non-textual outputs)

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Cite this